| MEASUREMENT PROPERTIES | |
| Limitations | English only |
| Observations | |
| 1. RELIABILITY | |
| A. Internal Consistency | Tested |
| Cronbach's (Describe) |
The Cronbach's alpha is 0.641 |
| B. Reliability intraobserver or test-retest | Not Tested |
| Continuous scores: intraclass correlation coefficient (ICC) Dichotomus: Cohen kappa (Describe) |
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| C. Reliability interobserver or Measurement error | Not Tested |
| Standard error of measurement (SEM), smallest detectable change (SDC) or Limits of agreement (LoA) (Describe) |
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| 2. VALIDITY | |
| A. Content validity: face validity | Tested |
| Expert opinion (relevance and comprehensiveness) (Describe) |
The MISA questionnaire fulfilled face validity as per the expert opinion of rheumatologists and it also fulfill content validity as it incorporated all usual unpleasant symptoms |
| B. Construct Validity: Structural validity |
Tested |
| Hypotheses-testing | Tested |
| Cross-cultural validity | Not Tested |
| Brief Description |
Questions in which scores were not significant (with p values >0.05) were removed and the refined questionnaire (10 questions) was called the MISA. |
| C. Criterion validity | Tested |
| Comparison with a 'gold standard' Continuous scores: correlations, ROC curves Dichotomus: Sensitivity & Specificity (Describe) |
On ROC analysis, the MISA score had a higher AUC of 0.904 (95% CI 0.838-0.971) compared to MISS with an AUC of 0.823 (95% CI 0.728-0.919) for MTX intolerance. On ROC analysis, MISA-CP had the highest AUC of 0.899 (95% CI 0.831-0.966) for discriminating moderate-severe intolerance. The AUC for MISS and MISA scores were 0.847 (95% CI 0.768-0.927) and 0.837 (95% CI 0.754-0.920) respectively (Figure 2). The optimal cut-off for MISA-CP was ≥4, with sensitivity and specificity of 93.5% and 77.3% respectively. |