| Name of the Instrument/Tool | Methotrexate Intolerance and Severity assessment in Adults (MISA) |
| First Description |
Vijaykumar D, Dhir V, Jain S, Pai V, Kaur J, Naidu GS, Sharma A, Khanna Sharma S, Jain S. Assessing methotrexate intolerance and its prevalence in rheumatoid arthritis: Development and validation of the MISA questionnaire. Int J Rheum Dis. 2021 Oct;24(10):1294-1301. |
| Year | 2021 |
| Domains | |
| Concept of constructs | Treatment tolerability |
| Population/Disease | Disease specific |
| Originally developed for | Rheumatoid Arthritis (RA) |
| Other rheumatic diseases where can be applied (only if validated) |
--- |
| Additional population with no rheumatic diseases |
No |
| Language: Originally published in | English |
| Available in Language | Hindi |
| REFERENCE IDENTIFICATION | |
| Author/s | Vijaykumar D, Dhir V, Jain S, Pai V, Kaur J, Naidu GS, Sharma A, Khanna Sharma S, Jain S. |
| Title | Assessing methotrexate intolerance and its prevalence in rheumatoid arthritis: Development and validation of the MISA questionnaire. |
| Journal | Int J Rheum Dis. |
| Year | 2021 |
| Vol | 24 |
| Num | 10 |
| Pages | 1294-1301 |
| Country | India |
| Language | English |
| Other references of interest | |
| No other References. | |
| Instrument/Tool Translations References | |
| No other References. | |
| DEVELOPER CONTACT INFORMATION | |
| Correspondence to | Varun Dhir |
| varundhir@gmail.com | |
| Address | Department of Internal Medicine (Rheumatology Division), Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. |
| Website | --- |
| Available | --- |
| Links | --- |
| DESCRIPTION OF THE INSTRUMENT | |
| Type Of Measure | Questionnaire |
| Brief Description |
New questionnaire (Methotrexate Intolerance and Severity assessment in Adults [MISA] questionnaire) for measuring MTX intolerance and its severity in RA patients. |
| Number of Items | 10 |
| Range | 0-24 |
| Responses options/scale |
Yes Questions 1-7: 0 to 3; Questions 8-10:0 or 1 |
| Developed for | --- |
| PRACTICAL APPLICATION | |
| Method of administration | Self-administered |
| Recommendations to score |
This score is calculated by adding the scores of the first 7 questions (0 to 3), to the last 3 questions (0 or 1). The sum of each independent score gives the final score. |
| Score Interpretation | Higher scores indicate higher intolerance. |
| Cut-off points | --- |
| Cut-off points applied to | --- |
| Smallest detectable change if described | --- |
| Smallest detectable change applied to | --- |
| Completion time by the patient | 5 minutes |
| Scoring time by the assessor | - minutes |
| Training to score | Not necessary |
| Strengths | Useful in clinical practice & research, Easy to use |
| Limitations | --- |
| OTHER COMMENTS | |
| Other Comments |
Sensitivity and specificity of 91.4% and 84.3% (cut-off ≥1), to detect MTX intolerance |