| MEASUREMENT PROPERTIES | |
| Limitations | English only |
| Observations |
GMIM was developed from databases from patients with chronic refractory gout who participated in two randomized 6 month clinical trials of pegloticase. |
| 1. RELIABILITY | |
| A. Internal Consistency | Not Tested |
| Cronbach's (Describe) | |
| B. Reliability intraobserver or test-retest | Not Tested |
| Continuous scores: intraclass correlation coefficient (ICC) Dichotomus: Cohen kappa (Describe) |
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| C. Reliability interobserver or Measurement error | Not Tested |
| Standard error of measurement (SEM), smallest detectable change (SDC) or Limits of agreement (LoA) (Describe) |
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| 2. VALIDITY | |
| A. Content validity: face validity | Tested |
| Expert opinion (relevance and comprehensiveness) (Describe) |
The measures comprising the composite outcome measure included sU, tophus area, SJC, TJC, PGA, flares, and pain. The first five were based on a repeated measures mixed effects model with backward elimination using data from the pegloticase RCTs; pain was added given the importance attributed to it by interviews of 30 patients with gout. |
| B. Construct Validity: Structural validity |
Not Tested |
| Hypotheses-testing | Not Tested |
| Cross-cultural validity | Not Tested |
| Brief Description | |
| C. Criterion validity | Not Tested |
| Comparison with a 'gold standard' Continuous scores: correlations, ROC curves Dichotomus: Sensitivity & Specificity (Describe) |
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