VALIDATION DATA

MEASUREMENT PROPERTIES
Limitations >=5 European languages (English)
Observations

74 language versions, 12 fully validated

The disease-specific ASQOL questionnaire can multidimensionally assess the QoL in patients, including physical functioning, role physical, bodily pain, general health, vitality, social function, role emotion, and mental health. 

 

1. RELIABILITY
A. Internal Consistency Tested
Cronbach's (Describe)

α = 0.89-0.92

The pooled Cronbach’s α coefficients scored as high and moderate quality of evidence of the ASQOL was 0.89 (95% CI 0.86 to 0.92)

B. Reliability intraobserver or test-retest Tested
Continuous scores: intraclass
correlation coefficient (ICC)
Dichotomus: Cohen kappa (Describe)

ICC = 0.91 (UK)

ICC = 0.92 (The Netherlands)

In a systematic review,  adequate to very good test–retest reliability of high quality of evidence was found for the ASQOL questionnaire (ICC values of 0.44 to 0.933).

C. Reliability interobserver or Measurement error Not Tested
Standard error of measurement (SEM),
smallest detectable change (SDC) or
Limits of agreement (LoA) (Describe)
2. VALIDITY
A. Content validity: face validity Tested
Expert opinion (relevance and
comprehensiveness) (Describe)

The ASQoL was developed in partnership between a group in the United Kingdom and the Netherlands following a series of patient interviews. An item bank was generated and distilled following a Rasch analysis and the removal of problematic items. An interview study among five patients found that most of the concepts were captured.

B. Construct Validity:
Structural validity
Tested
Hypotheses-testing Tested
Cross-cultural validity Tested
Brief Description

Scaling properties were tested using Rasch analyses. Conceptually, the ASQOL is based on a needs-based model of health.

C. Criterion validity Tested
Comparison with a 'gold standard' Continuous scores:
correlations, ROC curves Dichotomus:
Sensitivity & Specificity (Describe)

ASQoL scores differed significantly by whether the respondent was having a good or a bad day (disease activity), self perceived general health status, and self perceived AS severity. The convergent validity of the ASQOL questionnaire is weak to good.