| Name of the Instrument/Tool | Clinical Disease Activity Index (CDAI) |
| First Description |
Aletaha D, Nell VP, Stamm T, Uffmann M, Pflugbeil S, Machold K, Smolen JS. Acute phase reactants add little to composite disease activity indices for rheumatoid arthritis: validation of a clinical activity score. Arthritis Res Ther. 2005;7(4):R796-806 |
| Year | 2005 |
| Domains | |
| Concept of constructs | Disease activity |
| Population/Disease | Disease specific |
| Originally developed for | Rheumatoid Arthritis (RA) |
| Other rheumatic diseases where can be applied (only if validated) |
--- |
| Additional population with no rheumatic diseases |
No |
| Language: Originally published in | English |
| Available in Language | English |
| REFERENCE IDENTIFICATION | |
| Author/s | Aletaha D, Nell VP, Stamm T, Uffmann M, Pflugbeil S, Machold K, Smolen JS. |
| Title | Acute phase reactants add little to composite disease activity indices for rheumatoid arthritis: validation of a clinical activity score. |
| Journal | Arthritis Res Ther |
| Year | 2005 |
| Vol | 7 |
| Num | 4 |
| Pages | R796-806 |
| Country | Austria |
| Language | English |
| Other references of interest | |
| Link | https://pubmed.ncbi.nlm.nih.gov/16273793/ |
| Brief Description |
The Simplified Disease Activity Index (SDAI) and the Clinical Disease Activity Index (CDAI): a review of their usefulness and validity in rheumatoid arthritis. |
| Link | https://pubmed.ncbi.nlm.nih.gov/19772784/ |
| Brief Description |
Disease activity assessment of rheumatoid arthritis in daily practice: validity, internal consistency, reliability and congruency of the Disease Activity Score including 28 joints (DAS28) compared with the Clinical Disease Activity Index (CDAI). |
| Link | https://pubmed.ncbi.nlm.nih.gov/16273793/https://pubmed.ncbi … |
| Brief Description |
Test‐retest reliability of disease activity core set measures and indices in rheumatoid arthritis |
| Instrument/Tool Translations References | |
| Link | https://arthritis-research.biomedcentral.com/articles/10.118 … |
| Brief Description |
Although the CDAI does not need formal transcultural validation, as it is not purely a PRO, the wording of the patient global assessment included may need caution. |
| Link | https://bmcmusculoskeletdisord.biomedcentral.com/articles/10 … |
| Brief Description |
Comparison of the the performance of both CDAI and SDAI in evaluation of disease activity in Moroccan patients with RA. |
| DEVELOPER CONTACT INFORMATION | |
| Correspondence to | Daniel Aletaha |
| daniel.aletaha@meduniwien.ac.at | |
| Address | Department of Rheumatology, Medical University of Vienna, Vienna, Austria. |
| Website | --- |
| Available | Contact university tech transfer department for Industry-sponsored trials: Dr. Claudia Ballaun (claudia.ernst-ballaun@meduniwien.ac.at). |
| Links | --- |
| DESCRIPTION OF THE INSTRUMENT | |
| Type Of Measure | Composite Index |
| Brief Description |
The CDAI is analogous to the Simplified Disease Activity Index (SDAI). CDAI takes into account the following items:
|
| Number of Items | 4 |
| Range | 0-76 |
| Responses options/scale |
No |
| Developed for | Both |
| PRACTICAL APPLICATION | |
| Method of administration | Physician |
| Recommendations to score |
Add up all results: 28SJC + 28TJC + PrGA +PaGA |
| Score Interpretation | The higher the score the higher the disease activity, and it can be interpreted as remission (CDAI ≤2.8), low (2.8 < CDAI ≤ 10), moderate (10 < CDAI ≤ 22), or high (CDAI >22) |
| Cut-off points | REM≤2.8; LDA >2.8 to 10; MDA >10 to 22; HDA >22 |
| Cut-off points applied to | Both |
| Smallest detectable change if described | SDDs (MDC%) to detect a true improvement or deterioration with 95% confidence was 8.05 (10.6%) |
| Smallest detectable change applied to | --- |
| Completion time by the patient | - minutes |
| Scoring time by the assessor | 2-5 minutes |
| Training to score | Not necessary |
| Strengths | Easy to use, Useful in clinical practice & research |
| Limitations | --- |
| OTHER COMMENTS | |
| Other Comments | --- |